NF-κB can inhibit the expression of some important proteins in the insulin signaling pathway, such as glucose transporter 4 protein (GLUT4).168 TNFs stimulate fat cells to break down lipids, thereby increasing the level of free fatty acids in the blood and reducing insulin sensitivity. Persistent inflammation will lead to insulin resistance, which can further aggravate the systemic inflammatory response and cause a long-term imbalance of the inflammatory axis, affecting blood glucose metabolism. While adults today lose fewer teeth than previous generations, the oral health of American adults generally has not changed much in the past 20 years. Tooth decay, affecting 90% of adults aged 20 to 64 years, and gum disease, affecting almost 50% of adults aged 45 to 64 years, remain two of the most prevalent oral diseases.
Oral diseases disproportionately affect the most vulnerable and disadvantaged populations. People of low socioeconomic status carry a higher burden of oral diseases and this association remains across the life course, from early childhood to older age, and regardless of the country’s overall income level. It’s often the result of not taking care of your mouth and teeth.
If any of these symptoms are accompanied by a high fever and facial or neck swelling, you should seek emergency medical treatment. This regional summary draws on WHO’s Global oral health status report, published in 2022, which provides a comprehensive overview of the global oral… It’s possible that, in some people, oral lichen planus may be triggered by certain medications, mouth injury, infection or allergy-causing agents such as dental materials.
Increased inflammation causes your gums to begin to pull away from your teeth. This process creates pockets in which pus may eventually collect. This more advanced stage of gum disease is called periodontitis.
**Oral disease**, also known as periodontal disease, is a serious condition that affects the gums and bones supporting the teeth. If left untreated, it can lead to tooth loss and other health complications.
Causes of Oral Disease
It was found that in addition to increasing the secretion of IL-8 and MMP, oral cancer cells infected with live F. Nucleatum significantly induced higher expression of STAT3, MYC, and ZEB1.107 This indicates that in addition to promoting tumor proliferation through Toll-like receptors, F. Nucleatum can also promote tumor invasion and epithelial–mesenchymal transition. There is a two-way relationship between chronic periodontitis and Alzheimer’s disease. Due to limited mobility and poor oral hygiene in patients with Alzheimer’s disease, it promotes the accumulation of periodontal tissue inflammation and eventually leads to tooth loss. Because the loss of teeth affects the patient’s eating and nutritional status, it may worsen the patient’s memory and other nervous system functions.
If you show signs of a gum infection or you have a tooth abscess that has spread to other teeth or your jaw, your dentist may prescribe antibiotics to help get rid of the infection. The antibiotic may be in the form of a mouth rinse, gel, oral tablet, or capsule. Topical antibiotic gel may also be applied to the teeth or gums during surgical procedures. However, T lymphocytes — certain white blood cells involved in inflammation — appear to be activated in oral lichen planus. This could indicate an immune disorder, and genetic factors may be involved.
Treatment is costly and lengthy and sometimes can even lead to tooth loss, resulting in complications for facial and psychological development and quality of life. This pattern of inequalities is similar to other noncommunicable diseases such as cancers, cardiovascular diseases, diabetes, and mental disorders. Risk factors common to noncommunicable diseases such as high sugar intake, all forms of tobacco use, and harmful use of alcohol all contribute to the global oral health crisis. It has also been reported that in a case of a pregnant woman with gingivitis and upper respiratory tract infection who gave birth to a stillbirth, the 16S rRNA coding sequence analysis method was used to detect F.
The main cause of **oral disease** is poor oral hygiene. Plaque buildup on the teeth can lead to gum inflammation and infection. Smoking, hormonal changes, certain medications, and genetic factors can also increase the risk of developing oral disease.
Symptoms of Oral Disease
Common symptoms of oral disease include red, swollen gums, bleeding when brushing or flossing, bad breath, and loose teeth. If you experience any of these symptoms, it is important to see a dentist for a proper diagnosis and treatment.
Prevention and Treatment
Practicing good oral hygiene, such as brushing twice a day, flossing daily, and seeing a dentist regularly, can help prevent oral disease. Treatment options for oral disease may include deep cleaning, antibiotics, and surgery in severe cases.
Impact on Overall Health
Recent studies have shown a link between oral disease and other health conditions, such as heart disease, diabetes, and respiratory infections. Maintaining good oral health is essential for overall well-being.
