For the millions of people suffering from osteoarthritis, finding relief from the pain and stiffness associated with this condition is a top priority. Fortunately, there are several new treatments that are showing promise in managing the symptoms of osteoarthritis and improving overall quality of life for patients.
They then compared their findings to the current understanding of knee osteoarthritis in humans. The Wnt signaling pathway is transduced through a large family of Wnt glycoproteins (19 genes in mammals)56. Î’-Catenin is one of the important protein in canonical Wnt signaling, which regulates the development and homeostasis of joints57. Activation of the Wnt signaling pathway has been noted in the cartilage, bone, and synovial membrane in OA patients58,59.
Platelet-Rich Plasma Therapy
Results from the study showed that Link_TSG6 suppresses the production of enzymes implicated in cartilage damage – a hallmark of OA. Furthermore, administration of Link_TSG6 reduced cartilage breakdown, underpinning its potential as a DMOAD, and also reduced touch-evoked pain behaviour supporting a possible analgesic effect. Sprifermin is in clinical development to investigate its potential as a treatment for osteoarthritis (OA) in the knee. It is a truncated recombinant human FGF-18 protein thought to induce chondrocyte proliferation and increased extra-cellular matrix (ECM) production, with the potential of promoting cartilage growth and repair. MMPs are a family of zinc-dependent proteolytic enzymes that degrade the components of the extracellular matrix21. Although some of the developed MMP inhibitors have shown notable effects on preclinical OA models24,25,26,27,28, only a few have entered clinical trials for patients with mild-to-moderate knee OA (Fig. 1).
Doses of free cholesterol as recommended clinically resulted in overproduction of reactive oxygen species (ROS) and mitochondrial dysfunction. Hypertrophic and degradative markers were upregulated in chondrocytes, resulting in increased breakdown of the cartilage matrix. This section discusses new technologies and modalities emerging from the fundamental understanding of OA pathogenesis. Senescent chondrocytes accumulate in osteoarthritic cartilage and serve as a source of chronic inflammation in joints. The versatility of noncoding RNAs (ncRNAs) in regulating a broad range of targets has stimulated the recent focus on RNA therapeutics, and there are now several FDA-approved RNA-based therapeutics in the pharmaceutical market.
Platelet-rich plasma (PRP) therapy is a cutting-edge treatment that involves injecting a concentrated dose of a patient’s own platelets into the affected joint. These platelets contain growth factors that can help stimulate tissue repair and reduce inflammation, leading to improved function and decreased pain in the joint.
Because arthritic joints can be sensitive, see a massage therapist who specializes in treating people with arthritis. The pain and limited mobility in OA occur as the cartilage that cushions the space between bones wears away with age and overuse. Left bare of their padding, bones rub painfully against each other—particularly in the hands, spine, knees, and hips.
There’s a chance that, at some point in your life, you’ll develop osteoarthritis (OA). If you have Arthritis and want to live a happy and healthy life, call now to discuss your arthritis concerns, Dr. Mitra can help formulate a personalized treatment plan to help you find relief. So, it is essential to properly diagnose the diseased condition and determine the appropriate course of treatment.
During hip replacement surgery, your surgeon removes the diseased or damaged parts of your hip joint and inserts the artificial joint. Removing or adding a wedge of bone in your shinbone or thighbone can help straighten this bowing and shift your weight to the undamaged part of your knee joint. Many of these genes signify molecules that are the targets of existing approved drugs and drugs that are currently in clinical development. The study, published in the journal Cell on August 26, was led by the Helmholtz Center Munich in Germany.
Benefits of PRP Therapy:
- Non-surgical
- Minimal side effects
- Potential for long-lasting relief
Stem Cell Therapy
Stem cell therapy is another innovative approach to treating osteoarthritis that involves using a patient’s own stem cells to regenerate damaged tissues in the affected joint. This can help restore function and reduce pain, potentially delaying or even avoiding the need for surgery.
FAQs about Stem Cell Therapy:
- How does stem cell therapy work?
- Is stem cell therapy safe?
- What are the potential risks and benefits?
With these exciting new developments in osteoarthritis treatment, patients now have more options than ever before for managing their symptoms and improving their quality of life.
